Results 41 to 50 of about 812,609 (276)

The content of software production course [PDF]

open access: yes, 2017
Software production is an integral activity that encompasses the majority of computer science and information technologies knowledge and skills such as algorithms, programming, databases, networking etc.
Ivanov, Stanislav, Peneva, Juliana
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Handbook of Research on Visual Computing and Emerging Geometrical Design Tools [PDF]

open access: yes, 2016
Visual computing and descriptive geometry are multidisciplinary fields addressing the handling of images, 3D models, and other computer graphics. These ideas are experiencing a revival due to emergent technologies and applications available to developers.
Giuseppe, Amoruso
core  

Enhancing the Digital Backchannel Backstage on the Basis of a Formative User Study [PDF]

open access: yes, 2012
Contemporary higher education with its large audiences suffers from passivity of students. Enhancing the classroom with a digital backchannel can contribute to establishing and fostering active participation of and collaboration among students in the ...
Bry, François   +2 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Forecasting the Spreading of Technologies in Research Communities [PDF]

open access: yes, 2017
Technologies such as algorithms, applications and formats are an important part of the knowledge produced and reused in the research process. Typically, a technology is expected to originate in the context of a research area and then spread and ...
Mannocci, Andrea   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Arithmetic on a Distributed-Memory Quantum Multicomputer

open access: yes, 2007
We evaluate the performance of quantum arithmetic algorithms run on a distributed quantum computer (a quantum multicomputer). We vary the node capacity and I/O capabilities, and the network topology.
ACM.   +6 more
core   +1 more source

Revisión tecnológica del aprendizaje de idiomas asistido por ordenador: una perspectiva cronológica [PDF]

open access: yes, 2019
El presente artículo aborda la evolución y el avance de las tecnologías del aprendizaje de lenguas asistido por ordenador (CALL por sus siglas en inglés, que corresponden a Computer- Assisted Language Learning) desde una perspectiva histórica.
Gómez Parra, María Elena   +2 more
core   +1 more source

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