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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
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Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
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Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
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A Survey of Human-Computer Interaction into the Computer Science Curricula in Iberoamerica
2011 Eighth International Conference on Information Technology: New Generations, 2011As Computer Science has developed, Human-Computer Interaction (HCI) has gradually become part of its curriculum. Human-Computer Interaction is one of the most promising research areas in Computer Science field. In spite of its growth, it is hard to find in Iberoameric Computer Science programs that include HCI in an effective way into the curricula. In
César A. Collazos 0001 +2 more
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The Prospects for Psychological Science in Human-Computer Interaction
Human–Computer Interaction, 1985This paper discusses the prospects of psychology playing a significant role in the progress of human-computer interaction. In any field, hard science (science that is mathematical or otherwise technical) has a tendency to drive out softer sciences, even if the softer sciences have important contributions to make.
Allen Newell, Stuart K. Card
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Human–computer interaction: psychology as a science of design
International Journal of Human-Computer Studies, 1997▪ Abstract Human-computer interaction (HCI) study is the region of intersection between psychology and the social sciences, on the one hand, and computer science and technology, on the other. HCI researchers analyze and design specific user interface technologies (e.g. pointing devices).
John M Carroll
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Utility of human-computer interactions
Proceedings of the SIGCHI Conference on Human Factors in Computing Systems, 2011The success of a computer system depends upon a user choosing it, but the field of Human-Computer Interaction has little ability to predict this user choice. We present a new method that measures user choice, and quantifies it as a measure of utility. Our method has two core features.
Michael Toomim +3 more
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Creating a design science of Human-Computer Interaction
Interacting with Computers, 1993Abstract An increasingly important task of computer science is to support the analysis and design of computers as things to learn from, as tools to use in one's work, as media for interacting with other people. Human-computer interaction (HCI) is the speciality area that addresses this task.
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Bridging the gap between material science and human-computer interaction
Interactions, 2019Many interactive devices such as laptops and mobile phones currently have static, planar shapes that are arguably not particularly adapted to the user. Recent developments in display and material technologies have enabled explorations into morphing devices that can provide improved affordances for human interaction. From interactive spherical displays,
Isabel P. S. Qamar +3 more
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