Results 61 to 70 of about 1,025,786 (272)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin +12 more
wiley +1 more source
A Revised Publication Model for ECML PKDD [PDF]
, 2012 ECML PKDD is the main European conference on machine learning and data mining. Since its foundation it implemented the publication model common in computer science: there was one conference deadline; conference submissions were reviewed by a program ...
Blockeel, Hendrik +3 more
core +1 more source
Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco +18 more
wiley +1 more source
Efficient Machine Learning on Heterogeneous Computing Systems through a Coordinated Runtime System [PDF]
, 2019 Department of Computer Science and EngineeringAs machine learning grows, a heterogeneous computing system is actively used for a solution to increase the efficiency of machine learning. Although there are the prior studies for improving the efficiency of
Hyun, Jihoon
core
Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam +6 more
wiley +1 more source
Capturing human category representations by sampling in deep feature spaces [PDF]
, 2018 Understanding how people represent categories is a core problem in cognitive science. Decades of research have yielded a variety of formal theories of categories, but validating them with naturalistic stimuli is difficult.
Aghi, Krisha +4 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez +12 more
wiley +1 more source
Utilizing machine learning algorithms in computer science for drug repurposing
, 2021 Niela Rambocas, Claire B. Joseph
openalex +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu +9 more
wiley +1 more source