Results 101 to 110 of about 216,331 (260)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The total eclipse of bioinformatics: From disruption to convention, and a gentle warning. [PDF]

PLoS Comput Biol
Ouzounis CA.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Computer science and computer engineering research equipment

This grant supported acquisition of a minicomputer system for departmental research. The equipment selected is a DEC VAX-11/750 system, installed in remodeled space in the Computer Science (formerly Farm Crops) Building.
Tonge, Fred M.
core  

Teaching Software Verification and Validation Course: a Case Study

, 2014
Ozcelik, Erol/0000-0003-0370-8517; Cagiltay, Nergiz/0000-0003-0875-9276; Sengul, Gokhan/0000-0003-2273-4411Mishra, Alok/0000-0003-1275-2050; Mishra, Deepti/0000-0001-5144-3811Software verification and validation (V & V) is one of the significant areas of
Hacaloglu, Tuna, Mishra, Deepti, Mishra, Alok   +2 more
core  

Web-based collaborative model development in interdisciplinary consortia: Design principles and practical guidance. [PDF]

PLoS Biol
van Aalst M, Lahlou A, Hassan T, Gaultier W, Colliaux D, Matuszyńska A.   +5 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A UML-based Software Engineering Methodology for Agent Factory

, 2013
The 16th International Conference on Software Engineering and Knowledge Engineering (SEKE-2004), Banff, Alberta, Canada, 20-24th JuneThis paper presents the Agent Factory Development Methodology, an Agent-Oriented Software Engineering (AOSE ...
Rooney, Colm, O'Hare, G. M. P. (Greg M. P.), Collier, Rem, O\u27Hare, G. M. P. (Greg M. P.)   +3 more
core