Results 81 to 90 of about 32,982,640 (297)

Specifying computer-supported collaboration scripts [PDF]

, 2007
Collaboration scripts are activity programs which aim to foster collaborative learning by structuring interaction between learners. Computer-supported collaboration scripts generally suffer from the problem of being restrained to a specific learning ...
Kobbe, Lars, Weinberger, Armin, Fischer, Frank, Kobbe, L., Fischer, F., Häkkinen, P., Dillenbourg, Pierre, Harrer, Andreas, Harrer, A., Hämäläinen, R., Weinberger, A., Häkkinen, Päivi, Hämäläinen, Raija, Dillenbourg, P.   +13 more
core   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A comprehensive review of road segmentation, extraction, and classification from satellite imagery

Discover Geoscience
Road segmentation, extraction, and classification from satellite imagery are integral parts of geospatial analysis, enabling applications in urban planning, navigation, disaster management, and autonomous systems.
Mumbere Muyisa Forrest, Shiv Kumar Verma
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Ensuring academic integrity through automated online exam proctoring a decade long systematic review

Discover Education
Academic cheating in online examinations jeopardizes academic integrity and necessitates prompt intervention to uphold the credibility of digital assessments.
Manit Malhotra, Indu Chhabra
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A hybrid grey wolf and improved particle swarm optimization technique with Pareto knee selection for energy efficient load balancing in cloud computing

Discover Applied Sciences
In the realm of Cloud Computing, multi-objective task scheduling aims to map tasks to virtual machines while minimizing execution time, balancing load, and reducing cost.
Vaishali Mehta, Anu Gupta
doaj   +1 more source