The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
ASTWAS: modeling alternative polyadenylation and SNP effects in kernel-driven TWAS reveal novel genetic associations for complex traits. [PDF]
Wang Y +8 more
europepmc +1 more source
NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
Editorial on the Special Issue "Image and Video Processing for Blind and Visually Impaired". [PDF]
Zhu Z, Rizzo JR, Tang H.
europepmc +1 more source
Application of educational interventions based on gamification in prenatal healthcare: A systematic review of randomized controlled trials. [PDF]
Mehrabi R, Tavassoli T, Askari F.
europepmc +1 more source
Differences in usage and engagement rates of an online physical activity intervention among subgroups of adults aged 50 years and older in a practical setting. [PDF]
Collombon EHGM +4 more
europepmc +1 more source
Global landscape and professionalization of infection preventionist education: comparative insights and future directions. [PDF]
Cao YL +8 more
europepmc +1 more source
Observer: creation of a novel multimodal dataset for outpatient care research. [PDF]
Johnson KB +5 more
europepmc +1 more source

