Results 131 to 140 of about 3,363,328 (269)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

ANALYSIS OF FINE MOTOR CONTROL IN INSTITUTIONALIZED SHELTERED CHILDREN AND ADOLESCENTS THROUGH PERFORMANCE IN COMPUTER SOFTWARE. [PDF]

Rev Paul Pediatr, 2020
Araujo AW, Almeida RV, Crocetta TB, Monteiro CBM, Fernani DCGL, Dantas MTAP.   +5 more
europepmc   +1 more source

Dataset for Single Character Detection in Dongba Manuscripts

Scientific Data
The Dongba script, a unique pictographic writing system invented by the ancestors of the Naxi people of China, holds great significance for interpreting the ancient Naxi language, history, and culture.
Yuqi Ma, Yongbo Li, Guang Long, Ruiyuan Li, Fengyuan Hu, Chenjun Xu, Yueran Wang, Maoling Peng, Xiaoliang Li, Shanxiong Chen   +9 more
doaj   +1 more source

Audit Process during Projects for Development of New Mobile IT Application [PDF]

This paper presents characteristics of the computer audit process during software development life cycle focused on specific aspects of the mobile IT applications. There are highlighted specific features of the distributed informatics systems implemented
Marius POPA
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Automatic Sugarcane Disease Detection and Outbreak Alert System using Deep Learning

JISR on Computing
Agriculture Agriculture is a vital sector in Pakistan, with sugarcane being the second-largest crop. However, the industry faces challenges due to crop diseases, prompting the need for innovative solutions.
Munaf Rashid, Zuha Khan, Saeed Usmani, Asadullah Maliyawala, Kashif Iqbal   +4 more
doaj   +1 more source

Measurement of the properties of lossy materials inside a finite conducting cylinder [PDF]

A computer code was developed to automatically perform swept frequency reflection and transmission measurements using a HP5510B Network Analyzer and computer.
Caldecott, R., Dominek, A., Park, A.
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

In the soft-to-hard technical spectrum: Where is software engineering? [PDF]

In the computer journals and tabloids, there have been a plethora of articles written about the software engineering field. But while advocates of the need for an engineering approach to software development, it is impressive how many authors have ...
Leibfried, Theodore F., Macdonald, Robert B.   +1 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source