Results 131 to 140 of about 6,275,059 (295)

A documentation paradigm for an integrated software maintenance support environment [PDF]

, 1992
Recent advances in computer hardware have not been matched by comparable advances in computer software, inhibiting the production of reliable software at greater levels of productivity.
Bittlestone, David
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Data on the application of the molecular vector machine model: A database of protein pentafragments and computer software for predicting and designing secondary protein structures. [PDF]

Data Brief, 2020
Karasev V.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Dataset for Single Character Detection in Dongba Manuscripts

Scientific Data
The Dongba script, a unique pictographic writing system invented by the ancestors of the Naxi people of China, holds great significance for interpreting the ancient Naxi language, history, and culture.
Yuqi Ma, Yongbo Li, Guang Long, Ruiyuan Li, Fengyuan Hu, Chenjun Xu, Yueran Wang, Maoling Peng, Xiaoliang Li, Shanxiong Chen   +9 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

MATADOR: a magic matrix-based framework for tamper detection and image recovery

Journal of King Saud University: Computer and Information Sciences
Ensuring the integrity and authenticity of digital medical images is crucial for healthcare security and digital forensics, as image tampering can have serious consequences.
Thilina Mendis, Farah Kandah, Lalith Medury   +2 more
doaj   +1 more source

ANALYSIS OF FINE MOTOR CONTROL IN INSTITUTIONALIZED SHELTERED CHILDREN AND ADOLESCENTS THROUGH PERFORMANCE IN COMPUTER SOFTWARE. [PDF]

Rev Paul Pediatr, 2020
Araujo AW, Almeida RV, Crocetta TB, Monteiro CBM, Fernani DCGL, Dantas MTAP.   +5 more
europepmc   +1 more source

Software Effort Estimation Using Particle Swarm Optimization with Inertia Weight [PDF]

, 2011
Software is the most expensive element of virtually all computer based systems. For complex custom systems, a large effort estimation error can make the difference between profit and loss. Cost (Effort) Overruns can be disastrous for the developer.
CH.V.M.K.Hari, Dr. Prasad Reddy
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source