Results 161 to 170 of about 5,333,636 (301)

Exploring Older Adults' Video Game Use in the PRISM Computer System. [PDF]

Innov Aging, 2018
Boot WR, Moxley JH, Roque NA, Andringa R, Charness N, Czaja SJ, Sharit J, Mitzner T, Lee CC, Rogers WA.   +9 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Retraction: Design and development of human resource management computer system for enterprise employees. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Maze learning by a hybrid brain-computer system. [PDF]

Sci Rep, 2016
Wu Z, Zheng N, Zhang S, Zheng X, Gao L, Su L.   +5 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Essential Guide to Computer System Validation in the Pharmaceutical Industry. [PDF]

Cureus
Raja JR, Kella A, Narayanasamy D.
europepmc   +1 more source

Predicting Older Adults' Perceptions about a Computer System Designed for Seniors. [PDF]

Univers Access Inf Soc, 2016
Mitzner TL, Rogers WA, Fisk AD, Boot WR, Charness N, Czaja SJ, Sharit J.   +6 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Specialized Infrared Camera-Computer System (SPY) Imaging for Monitoring the Restoration of Nipple Sensation in Patients Undergoing Breast Reduction. [PDF]

Cureus
Celso B, Murray N, Murray J.
europepmc   +1 more source

Perceptions of Computer System Usefulness: Insights for Design from Experienced Older Users. [PDF]

Hum Asp IT Aged Popul (2015), 2015
Mitzner TL, Charness N, Rogers WA.
europepmc   +1 more source