Results 91 to 100 of about 743,425 (266)

Computing with dynamical systems

2016 IEEE International Conference on Rebooting Computing (ICRC), 2016
The effort to develop larger-scale computing systems introduces a set of related challenges: Large machines are more difficult to synchronize. The sheer quantity of hardware introduces more opportunities for errors. New approaches to hardware, such as low-energy or neuromorphic devices are not directly programmable by traditional methods.
Fred Rothganger, Conrad D. James, James B. Aimone   +2 more
openaire   +2 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

PASSWORD HASHING METHODS AND ALGORITHMS ON THE .NET PLATFORM

Сучасні інформаційні системи
Web applications, which are widely used to provide services and collect information, have become a major target for attackers, especially with the emergence of government services that process sensitive data.
Volodymyr Fedorchenko , Olha Yeroshenko , Oleksandr Shmatko , Oleksii Kolomiitsev , Murad Omarov   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Computability of Agentic Systems

CoRR
This paper introduces the Quest Graph, a formal framework for analyzing the capabilities of agentic systems with finite context. We define abstractions that model common reasoning techniques and establish their computational power: the base Quest Graph is equivalent to an unrestricted Turing machine; the forward-only Finite Quest Decision Process (FQDP)
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

THE USE OF MODERN INFORMATION TECHNOLOGIES DURING AERIAL RECONNAISSANCE

Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2015
Nowadays, using aerial reconnaissance, as a component of an armed forces intelligence system, become the undeniable factor that allows to promptly obtain an information about the enemy location and its possible actions.
Olexander Slusarchuk
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

EDUCATIONAL OBJECTIVES IN INTELLIGENT TUTORS FOR COMMUNICATION SKILLS [PDF]

Annals of the University of Petrosani: Economics, 2015
Intelligent Tutoring Systems have been successfully used to simulate human tutoring in various fields such as mathematics, physics or computer programming.
CIPRIAN CUCU
doaj  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source