Results 161 to 170 of about 12,647,201 (315)

THE EVOLUTION OF INFORMATION AND COMMUNICATION TECHNOLOGY OF EDUCATION OF STUDENTS AT HIGHER EDUCATIONAL INSTITUTIONS OF UKRAINE IN 90-s XX CENTURY – BEGINNING OF XXI CENTURY

open access: yesÌнформаційні технології в освіті, 2014
The article presents results of analysis research of the evolution of information and communication technology of education of students in higher educational institutions of Ukraine with 90-s XX century until today.
O. Voronkin
doaj  

Characterization of emotional speech in human-computer dialogues

open access: yes, 2003
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.Includes bibliographical references (p. 71-74).by Alicia D.
Boozer, Alicia D. (Alicia Denise), 1977-
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

USING COMPUTER TECHNOLOGY IN INTERSUBJECT PROJECTS OF PHYSICS DURING THE STUDY PRACTICE.

open access: yesÌнформаційні технології в освіті, 2010
This article discusses the use of computer technology in the performance of students in physics interdisciplinary projects during the academic practice.
N. Guy
doaj  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Computer support for home-based health care

open access: yes, 2001
Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2001.Includes bibliographical references (leaves 75-76).by Kartik M.
Mani, Kartik M., 1978-
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

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