Results 221 to 230 of about 109,737 (291)

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Advanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie   +12 more
wiley   +1 more source

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

Advanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
wiley   +1 more source

Bridging Global Frameworks and Local Practice: Quantitative Evaluation of Electronic Health Record Safety in Kuwait's Public Hospitals.

JMIR Med Inform
AlHussainan A, Alhuwail D.
europepmc   +1 more source

Mapping study on AI-based technologies in palliative care - a scoping study. [PDF]

BMC Palliat Care
Silva-Ferreira M, Cruz S, Luís MS, Silva MC, Monteiro-Reis S, Henrique R, Jerónimo C, Lefèvre SC, Laplaud A, Frasca M, Pollet L, Zurbanobeaskoetxea L, Barbastro RA, García MIH, Galán BJ, Palau FG, Marques DF, Durán RL.   +17 more
europepmc   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

International visualization analysis of research hotspots and development trends in the study of clinical decision support systems utilizing CiteSpace. [PDF]

Front Med (Lausanne)
Song M, Liu D.
europepmc   +1 more source

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

Advanced Science, EarlyView.
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang, Qinyu Li, Zijie Li, Xuejiao Wang, Hui Yuan, Pingting Yang, Ling Qin   +6 more
wiley   +1 more source

Frequent use of online medical records: analysis of influence factors based on structural equation modeling. [PDF]

Front Public Health
Wang W, Qin L, Chen Y, Wang Y, Ye L, Wang R, Zhu Y.   +6 more
europepmc   +1 more source

Directing the Mobility of Guest Molecules in Nanoporous Materials by Linearly Polarized Light

Advanced Science, EarlyView.
The polarization of light is introduced as a further parameter to dynamically and reversibly control the properties of a photoresponsive nanoporous material. It was used to control the mobility of the guest molecules in the pores of a metal–organic framework.
Taher Al Najjar, Chun Li, Yunzhe Jiang, Anna Mauri, Modan Liu, Abhinav Chandresh, Anemar Bruno Kanj, Dragos Mutruc, Wolfgang Wenzel, Stefan Hecht, Mariana Kozlowska, Lars Heinke   +11 more
wiley   +1 more source

Evaluating the Wasfaty E-Prescribing Platform Against Best Practices for Computerized Provider Order Entry. [PDF]

Healthcare (Basel)
Alkathiri S, Alothman R, Ata S, Alruthia Y.   +3 more
europepmc   +1 more source