Results 241 to 250 of about 211,001 (366)

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng   +11 more
wiley   +1 more source

Optimizing Clinical Decision Support System Functionality by Leveraging Specific Human-Computer Interaction Elements: Insights From a Systematic Review.

JMIR Hum Factors
Azadi A, García-Peñalvo FJ.
europepmc   +1 more source

Data Interoperability and Harmonization in Cardiovascular Genomic and Precision Medicine. [PDF]

Circ Genom Precis Med
Chahal CAA, Alahdab F, Asatryan B, Addison D, Aung N, Chung MK, Denaxas S, Dunn J, Hall JL, Pamir N, Slotwiner DJ, Vargas JD, Armoundas AA.   +12 more
europepmc   +1 more source

Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice

Advanced Science, EarlyView.
PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu, Jin‐Yin Huang, Xing‐Zhe Xu, Ji‐Yu Sun, Dan‐Ni Zou, Jia‐Yao Zhang, Chen Chi, Qi Zhang, Wei‐Cai Liu   +8 more
wiley   +1 more source

Artificial intelligence and robotic surgery in clinical medicine: progress, challenges, and future directions. [PDF]

Future Sci OA
Beyaz S, Özgözen AL, Turgut N, Ölke HC.   +3 more
europepmc   +1 more source

BrainFusion: a Low‐Code, Reproducible, and Deployable Software Framework for Multimodal Brain‒Computer Interface and Brain‒Body Interaction Research

Advanced Science, EarlyView.
BrainFusion is a low‐code software framework for multimodal brain–computer interface (BCI)​​ and brain–body interaction research. It supports ​electroencephalography (EEG)​, functional near‐infrared spectroscopy (fNIRS), electromyography (EMG)​, and electrocardiography (ECG)​​ integration with standardized preprocessing, feature fusion, and model ...
Wenhao Li, Chenyang Gao, Zhaobo Li, Yunheng Diao, Jiaxin Li, Jiayi Zhou, Jing Zhou, Ying Peng, Guanchu Chen, Xuecheng Wu, Kai Wu   +10 more
wiley   +1 more source

Digital Therapeutics for Cognitive Impairment: Exploring Innovations, Challenges, and Future Prospects.

J Med Internet Res
Zang GY, Rao K, Wu J, He Y, Tang Y, Shi L.   +5 more
europepmc   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

[A computerized medical record system for primary health care].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1983
J F, Nilsen, S, Fosse
openaire   +3 more sources

Patient Perspectives on Digital Technology and Experiences of Computerized History-Taking for Chest Pain Management in the Emergency Department: CLEOS-CPDS Prospective Cohort Study.

JMIR Med Inform
Fritzell K, Brandberg H, Spaak J, Koch S, Sundberg CJ, Zakim D, Kahan T, Sundberg K.   +7 more
europepmc   +1 more source