Results 31 to 40 of about 27,278 (304)

User-centered visual analysis using a hybrid reasoning architecture for intensive care units [PDF]

, 2012
One problem pertaining to Intensive Care Unit information systems is that, in some cases, a very dense display of data can result. To ensure the overview and readability of the increasing volumes of data, some special features are required (e.g., data ...
Mehdaoui, Hossein, Zennir, Youcef, Hubert, Hervé, Kamsu-Foguem, Bernard, Lemdani, Mohamed, Tchuenté Foguem, Germaine, Allart, Laurent, Vilhelm, Christian, Zitouni, Djamel, Ravaux, Pierre   +9 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Modelling Access Control For Healthcare Information Systems [PDF]

, 2007
The widening use of Information Systems, which allow the collection, extraction, storage, management and search of information, is increasing the need for information security.
Ferreira, Ana, Antunes, Luis, Chadwick, David W.   +2 more
core  

Tensions and paradoxes in electronic patient record research: a systematic literature review using the meta-narrative method

, 2009
Background: The extensive and rapidly expanding research literature on electronic patient records (EPRs) presents challenges to systematic reviewers. This literature is heterogeneous and at times conflicting, not least because it covers multiple research
Bark, P., Swinglehurst, D., GEOFF WONG, Wong, G., TRISHA GREENHALGH, Potts, HW, PIPPA BARK, Greenhalgh, T, Wong, G, Greenhalgh, Trisha, DEBORAH SWINGLEHURST, Greenhalgh, T., Swinglehurst, D, HENRY W.W. POTTS, Potts, H.W.W., Bark, P   +15 more
core   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Building a house on shifting sand: methodological considerations when evaluating the implementation and adoption of national electronic health record systems. [PDF]

, 2012
Copyright @ 2012 Takian et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use ...
Takian Amirhossein, Takian, A, Barber, N, Petrakaki, Dimitra, Tony Cornford (12616102), Petrakaki Dimitra, Barber Nicholas, Amirhossein Takian (6528590), Petrakaki, D, Evaluat, NNHSCRS, ?, ?, Barber, Nicholas, Takian, Amirhossein, Sheikh, A, Cornford Tony, Nicholas Barber (758701), Sheikh Aziz, Dimitra Petrakaki (4463542), Cornford, T, Cornford, Tony, Sheikh, Aziz, Aziz Sheikh (18504)   +21 more
core   +1 more source

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li, Guilin Meng, Zijie Wang, Xiao Hu, Jing Cheng, Chu Chen, Tiannan Yang, Jiaxin Luo, Zizhen Meng, Xueyun Liu, Qi Li   +10 more
wiley   +1 more source

Informatics as Tool for Quality Improvement: Rapid Implementation of Guidance for the Management of Chronic Kidney Disease in England as an Exemplar [PDF]

Healthcare Informatics Research, 2013
ObjectivesChronic kidney disease (CKD) is an important cause of excess cardiovascular mortality and morbidity; as well as being associated with progression to end stage renal disease. This condition was largely unheard of in English primary care prior to
Simon de Lusignan
doaj   +1 more source