Results 141 to 150 of about 5,169,614 (387)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Thermal Performance Analysis and Structural Optimization of Main Functional Components of Computers

open access: yesApplied Sciences
In today’s data-driven age, the thermal properties of computer transistors play an important role. In this research, finite element simulation is employed to construct the structural model of the primary components within a computer chassis, and the ...
Tengyue Pan   +9 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Comparison of Perceived Musculoskeletal Discomfort Among Six Common Postures for Laptop Use in Female Students

open access: yesPhysical Treatments, 2018
Purpose: The present study aimed to compare Musculoskeletal Discomforts (MSDs) among six different common postures while working with laptop in female students of University of Tehran, Tehran City, Iran.
Nahid Allafan   +4 more
doaj  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Computational geometry and discrete computations [PDF]

open access: yes, 1996
In this paper we describe some problems arising in practical implementation of algorithms from computational geometry. Going to robust algorithms needs to solve issues such as rounding errors and degeneracies. Most of the problems are closely related to the incompatibility between on one side algorithms designed for continuous data and on the other ...
openaire   +3 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

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