Results 191 to 200 of about 5,169,614 (387)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Using encryption for authentication in large networks of computers

CACM, 1978
R. Needham, M. D. Schroeder
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Application of Multisensor Information Fusion Technology in the Measurement of Dynamic Machining Errors of Computer Numerical Control (CNC) Machine Tools [PDF]

, 2021
LI Xiao-ping, Yonghong Deng, Xuezhe Li
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

The Use of Rational Functions in the Iterative Solution of Equations on a Digital Computer [PDF]

, 1965
P. Jarratt, D. Nudds
openalex   +1 more source

Predictive, preventive, and personalized management of retinal fluid via computer-aided detection app for optical coherence tomography scans

, 2022
Ten Cheer Quek, Kengo Takahashi, Hyun Goo Kang, Sahil Thakur, Mihir Deshmukh, Rachel Marjorie Wei Wen Tseng, Helen Nguyen, Yih Chung Tham, Tyler Hyungtaek Rim, Sung Soo Kim, Yasuo Yanagi, Gerald Liew, Ching‐Yu Cheng   +12 more
openalex   +2 more sources

Assessment of Active Wheelset Steering System Using Computer Simulations and Roller Rig Tests [PDF]

, 2021
Jan Kalivoda, Petr Bauer, Zdeněk Novák
openalex   +1 more source

PsyScope: An interactive graphic system for designing and controlling experiments in the psychology laboratory using Macintosh computers

, 1993
J. Cohen, B. MacWhinney, M. Flatt, Jefferson Provost   +3 more
semanticscholar   +1 more source