Results 31 to 40 of about 1,405,349 (273)

Duality and Recycling Computing in Quantum Computers [PDF]

open access: yes, 2007
Quantum computer possesses quantum parallelism and offers great computing power over classical computer \cite{er1,er2}. As is well-know, a moving quantum object passing through a double-slit exhibits particle wave duality. A quantum computer is static and lacks this duality property.
arxiv   +1 more source

Marvel DC: A Blockchain-Based Decentralized and Incentive-Compatible Distributed Computing Protocol [PDF]

open access: yesarXiv, 2022
Decentralized computation outsourcing should allow anyone to access the large amounts of computational power that exists in the Internet of Things. Unfortunately, when trusted third parties are removed to achieve this decentralization, ensuring an outsourced computation is performed correctly remains a significant challenge. In this paper, we provide a
arxiv  

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

open access: yesFEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa   +8 more
wiley   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

Unconventional Quantum Computing Devices [PDF]

open access: yesin `Unconventional Models of Computation,' C.S. Calude, J. Casti, M.J. Dinneen, eds., Springer, Singapore, 1998, 2000
This paper investigates a variety of unconventional quantum computation devices, including fermionic quantum computers and computers that exploit nonlinear quantum mechanics. It is shown that unconventional quantum computing devices can in principle compute some quantities more rapidly than `conventional' quantum computers.
arxiv  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Computational models for parallel computers [PDF]

open access: yesPhilosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences, 1988
Computational models define the usage patterns of a computer. They can be used to derive the architecture of the machine, provide guidelines for programming tools, and suggest how the machine should be used in applications. Identifying computational models is especially important for parallel computers, because their architectures and usages are still ...
openaire   +2 more sources

A Survey of Current Trends in Distributed, Grid and Cloud Computing [PDF]

open access: yesInternational Journal of Advanced Studies in Computers, Science & Engineering (IJASCSE Vol 2, Issue 3, 2013), 2013
Through the 1990s to 2012 the internet changed the world of computing drastically. It started its journey with parallel computing after it advanced to distributed computing and further to grid computing. And in present scenario it creates a new world which is pronounced as a Cloud Computing [1]. These all three terms have different meanings.
arxiv  

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