Results 81 to 90 of about 4,518,457 (289)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Computer/computer interface [PDF]

open access: yes, 1975
System synchronizes data transfer between two computers by generating data strobe pulses when computers are ready for data transfer.
Anderson, T. O.
core   +1 more source

Virtually No Effect? Different Uses of Classroom Computers and Their Effect on Student Achievement

open access: yesSocial Science Research Network, 2015
Most studies find little to no effect of classroom computers on student achievement. We suggest that this null effect may combine positive effects of computer uses without equivalently effective alternative traditional teaching practices and negative ...
Oliver Falck   +2 more
semanticscholar   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Almost-classical quantum computers [PDF]

open access: yes, 2010
By means of a subgroup of the 2 X 2 unitary matrices, i.e. a subgroup Q of U(2), acting on a single qubit, we create a group X, acting on w qubits. If Q equals the group of order 2 consisting of the follower and the inverter, we recover S_{2^w}, i.e. the
Boes, Michiel   +2 more
core   +1 more source

The Gathering — nerdenes Mekka

open access: yesKulturella Perspektiv, 2001
"The Gathering" is an established Easter ritual among the young devoted to high-technology in Norway. For five days hordes of young computer freaks gather in the city of Hamar.
Birgit Hertzberg Johnsen
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

Behaviour of students in the market of information services

open access: yesПутеводитель предпринимателя, 2020
In article questions of occurrence of students in information society, information sources, information consumption, participation of students in forsayt-project creation, use of computers and other technical means in obtaining information, a condition ...
E. V. Kovalevskaya
doaj  

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

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