Results 71 to 80 of about 4,892,723 (368)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Functional computation as concurrent computation [PDF]

Proceedings of the 23rd ACM SIGPLAN-SIGACT symposium on Principles of programming languages - POPL '96, 1996
We investigate functional computation as a special form of concurrent computation. As formal basis, we use a uniformly confluent core of the π-calculus, which is also contained in models of higher-order concurrent constraint programming. We embed the call-by-need and the call-by-value λ-calculus into the π-calculus.
openaire   +2 more sources

Conocimientos sobre alfabetización informacional en profesionales de la salud Knowledge about information literacy in health professionals

Revista Cubana de Medicina General Integral, 2013
Introducción: la alfabetización informacional es importante para aprovechar las ventajas de la investigación disponible en diferentes formatos. Objetivo: determinar el conocimiento que tienen los profesionales de la salud sobre la alfabetización ...
Xiomara García Hernández, Miguel Lugones Botell   +1 more
doaj  

Quantum Computing

, 2010
Quantum mechanics---the theory describing the fundamental workings of nature---is famously counterintuitive: it predicts that a particle can be in two places at the same time, and that two remote particles can be inextricably and instantaneously linked ...
A Andre, A Batra, A Gaëtan, A Gruber, A Khitun, A Lupascu, A Micheli, A Mizel, A Politi, A Wallraff, A Yang, AJ Shields, AO Niskanen, B Trauzettel, BD Gerardot, BE Kane, C Kistner, C Langer, C Nayak, C Negrevergne, C Ospelkaus, C Piermarocchi, C Schneider, C Wang, C. Monroe, CA Ryan, CA Ryan, CB Simmons, CF Wang, CHW Barnes, D Leibfried, D Press, D Vion, D Wineland, DE Chang, DG Cory, DJ Wineland, DP DiVincenzo, E Knill, E Knill, E Knill, E Urban, E Wu, F. Jelezko, G Balasubramanian, GF Quinteiro, H de Riedmatten, H Schmidt, HW Liu, I Chiorescu, I Fushman, J Benhelm, J Berezovsky, J Emerson, J Harrison, J. L. O’Brien, JA Schreier, JCF Matthews, JJ Garcia-Ripoll, JJL Morton, JL O’Brien, JL O’Brien, JM Martinis, JP Home, K Sanaka, L DiCarlo, L Jiang, L Rippe, L Tian, L Tian, L-M Duan, LM Duan, LMK Vandersypen, M Anderlini, M Ansmann, M Atatüre, M Mehring, MA Nielsen, MN Leuenberger, MVG Dutt, N Khaneja, N Mason, NA Gershenfeld, O Morsch, P Bertet, P Neumann, P Recher, P Treutlein, PM Platzman, PW Shor, R Hanson, R Hanson, R Hanson, R Raussendorf, R Raussendorf, R Vrijen, R. Laflamme, RH Hadfield, S Olmschenk, S Takahashi, SG Uhrig, SJ Devitt, SL Braunstein, SL Braunstein, T. D. Ladd, TD Ladd, V Privman, VN Smelyanskiy, W Dür, Y Nakamura, Y. Nakamura   +110 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Quantum computing and simulation

Nanophotonics, 2020
Quantum computers and simulators can have an extraordinary impact on our society. Despite the extraordinary progress they have made in recent years, there are still great challenges to be met and new opportunities to be discovered.
Cirac Juan Ignacio
doaj   +1 more source

Polychronous Oscillatory Cellular Neural Networks for Solving Graph Coloring Problems

IEEE Open Journal of Circuits and Systems, 2023
This paper presents polychronous oscillatory cellular neural networks, designed for solving graph coloring problems. We propose to apply the Potts model to the four-coloring problem, using a network of locally connected oscillators under superharmonic ...
Richelle L. Smith, Thomas H. Lee
doaj   +1 more source

(Tissue) P Systems with Anti-Membranes [PDF]

, 2019
The concept of a matter object being annihilated when meeting its corresponding anti-matter object is taken over for membranes as objects and anti-membranes as the corresponding annihilation counterpart in P systems. Natural numbers can be represented
Alhazov, Artiom, Freund, Rudolf, Ivanov, Sergiu, Research Group on Natural Computing (Coordinador)   +3 more
core  

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

A Survey of Security in Cloud, Edge, and Fog Computing

Sensors, 2022
The field of information security and privacy is currently attracting a lot of research interest. Simultaneously, different computing paradigms from Cloud computing to Edge computing are already forming a unique ecosystem with different architectures ...
Aleksandr Ometov, Oliver Liombe Molua, Mikhail Komarov, Jari Nurmi   +3 more
doaj   +1 more source