Results 81 to 90 of about 1,105,055 (318)

L’écriture collective du code source informatique

open access: yesRevue d'anthropologie des connaissances, 2012
This article analyzes the collective writing of software source code. Software source code is a set of textual documents that formally specify the behavior of software – its script. The article draws on work in the sociology of science and technology and
Stéphane Couture
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

open access: yesFEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia   +5 more
wiley   +1 more source

Computability and Non-computability Issues in Amorphous Computing [PDF]

open access: yes, 2012
Amorphous computing systems consist of a huge set of tiny simple stationary or mobile processors whose computational, communication and sensory part is reduced to an absolute minimum. In an airborne medium the processors communicate via a short-range radio while in a waterborne medium via molecular communication. In some cases the computational part of
openaire   +3 more sources

Editorial: Exploring human subjectivity

open access: yesFrontiers in Psychology, 2023
Esteban Laso Ortiz   +2 more
doaj   +1 more source

Comparison of gender relation to information and communication technologies at the to BERG Faculty [PDF]

open access: yesActa Montanistica Slovaca, 2005
The contribution deals with the valuation of computer literacy poll and students‘ readiness to ICT (Information and Communication Technologies) at the beginning of the academic study. The questionnaire was realized in the electronic form and was oriented
Pavel Horovčák
doaj  

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

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