Results 111 to 120 of about 2,831 (235)

Structural and Vascular Features of Macula Related to the Recurrence of Macular Edema in Central Retinal Vein Occlusion After Anti‐VEGF Therapy

Journal of Ophthalmology, Volume 2025, Issue 1, 2025.
Purpose: To identify the structural and vascular features of the macula related to the recurrence of macular edema (ME) in central retinal vein occlusion (CRVO) after intravitreal anti‐VEGF injections. Methods: This was a cross‐sectional study including CRVO patients without ME and age‐matched individuals.
Dazhuang Ren, Cece Zhao, Gaoxu Wei, Xiaoyun Hou, Chang Li, Zhiqing Li, Akio Oishi   +6 more
wiley   +1 more source

Intraocular Pharmacokinetics and Safety of Subretinal Injection Compared with Intravitreal Application of Conbercept in Vitrectomized Rabbit Eyes

Journal of Ophthalmology, 2020
Purpose. To evaluate the ocular pharmacokinetic properties of subretinal conbercept injection in vitrectomized rabbit eyes and to compare them with those by intravitreal injection. Methods.
Teng-teng Yao, Xiao-liang Jin, Yuan Yang, Yi-xiao Wang, Ya-li Zhou, Fang-lin He, Zhao-yang Wang   +6 more
doaj   +1 more source

Current developments of gene therapy in human diseases

MedComm, Volume 5, Issue 9, September 2024.
Gene therapy has seen remarkable advancements in recent decades, demonstrating its immense potential in treating a wide range of genetic and acquired diseases. Several AAV gene therapy products have been introduced to the market, addressing various conditions.
Fanfei Liu, Ruiting Li, Zilin Zhu, Yang Yang, Fang Lu   +4 more
wiley   +1 more source

Innovative Nanotechnology in Drug Delivery Systems for Advanced Treatment of Posterior Segment Ocular Diseases

Advanced Science, Volume 11, Issue 32, August 27, 2024.
The revolutionary nanotechnology brings hope to posterior segment ocular diseases. This review delves into the challenges of conventional drug delivery and the advantages of diverse nanomaterials in enhancing drug stability, targeting, and permeability by targeting VEGF, ROS, macrophages.
Yue Wu, Xin Li, Xueyu Fu, Xiaomin Huang, Shenrong Zhang, Nan Zhao, Xiaowei Ma, Qimanguli Saiding, Mei Yang, Wei Tao, Xingtao Zhou, Jinhai Huang   +11 more
wiley   +1 more source

Genome Editing VEGFA Prevents Corneal Neovascularization In Vivo

Advanced Science, Volume 11, Issue 25, July 3, 2024.
Corneal neovascularization (CNV) is a common clinical finding observed in various eye diseases, which can lead to blindness. Using the gene editing technology CRISPR/Cas9, sgRNA is selected to regulate the VEGFA gene expression that promotes neovascularization, thereby achieving therapeutic purposes.
Zhenhai Zeng, Siheng Li, Xiuhong Ye, Yiran Wang, Qinmei Wang, Zhongxing Chen, Ziqian Wang, Jun Zhang, Qing Wang, Lu Chen, Shuangzhe Zhang, Zhilin Zou, Meimin Lin, Xinyi Chen, Guoli Zhao, Colm McAlinden, Hetian Lei, Xingtao Zhou, Jinhai Huang   +18 more
wiley   +1 more source

Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and meta-analysis [PDF]

Background: Diabetic retinopathy is a major cause of sight loss in people with diabetes. The most severe form, proliferative diabetic retinopathy, carries a high risk of vision loss, vitreous haemorrhage, macular oedema and other harms.
Bojke L, Dias S, Fulbright H, Hodgson R, Lawrenson JG, Llewellyn A, Peto T, Rush T, Simmonds M, Steel D, Stewart L, Walker R, Walton M   +12 more
core   +1 more source

Safety and efficacy of intravitreal injection of conbercept for the treatment of patients with choroidal neovascularization secondary to pathological myopia: Results from the SHINY study

Acta Ophthalmologica, Volume 102, Issue 4, Page e577-e586, June 2024.
Abstract Purpose To evaluate the safety and efficacy of intravitreal injections of 0.5 mg conbercept in patients with choroidal neovascularization secondary to pathological myopia (pmCNV). Methods The 177 pmCNV patients were randomly assigned in a 3:1 ratio to receive conbercept or sham injection, respectively.
Liqin Gao, Yanping Song, Xiaodong Sun, Junjun Zhang, Yuling Liu, Youxin Chen, Zhifeng Wu, Ye Jian, Xiaoling Liu, Lin Lv, Shaojun Chen, Yu‐sheng Wang, Nan Chen, Xiao Ke, Feng Zhang   +14 more
wiley   +1 more source

A Nucleic Acid‐Based LYTAC Plus Platform to Simultaneously Mediate Disease‐Driven Protein Downregulation

Advanced Science, Volume 11, Issue 13, April 3, 2024.
A LYTAC Plus hydrogel that combines gene silencing and protein degradation capabilities is engineered through nucleic acid self‐assembly. By simultaneously downregulating the VEGFR‐2 and ANG‐2 levels, LYTAC Plus hydrogel designed for alleviating neovascular age‐related macular degeneration (n‐AMD) shows a better therapeutic efficacy compared to the ...
Yangyang Huang, Xujiao Zhou, Yirou Zhang, Miao Xie, Fujun Wang, Jingcan Qin, Han Ye, Hong Zhang, Chuan Zhang, Jiaxu Hong   +9 more
wiley   +1 more source

RETRACTED: Efficacy of anti‐vascular endothelial growth factor and mitomycin C on wound healing after trabeculectomy in glaucoma patients: A meta‐analysis

International Wound Journal, Volume 21, Issue 4, April 2024.
Abstract Trabeculectomy is the main surgical treatment for glaucoma, but scar formation during wound healing may lead to surgical failure. In this study, we evaluated the efficacy of anti‐vascular endothelial growth factor (anti‐VEGF) and mitomycin C (MMC) on wound healing after glaucoma surgery.
Wenlong Liu, Bang Liu
wiley   +1 more source

The efficacy and safety of anti-vascular endothelial growth factor combined with Ahmed glaucoma valve implantation in the treatment of neovascular glaucoma: a systematic review and meta-analysis [PDF]

BackgroundThe intraocular injections of anti-vascular endothelial growth factor (anti-VEGF) demonstrates significant efficacy in inhibiting the formation of ocular neovascularization in neovascular glaucoma (NVG). Ahmed glaucoma valve implantation (AGVI)
Chang-Zhu He, Fu-Li Xue, Jun-Qiao Liu, Qin Qiu, Song-Jie Lu, Yu He, Zhao-Jun Zeng   +6 more
core   +1 more source