Results 51 to 60 of about 60,468 (320)

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Concatenated Quantum Codes [PDF]

, 1996
One of the main problems for the future of practical quantum computing is to stabilize the computation against unwanted interactions with the environment and imperfections in the applied operations.
Knill, Emanuel, Laflamme, Raymond
core   +4 more sources

The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep

Advanced Science, EarlyView.
Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller, Anton Filipchuk, Sophie Bagur, Brice Bathellier   +3 more
wiley   +1 more source

Adaptive Syndrome Extraction

PRX Quantum
Device error rates on current quantum computers have improved enough to where demonstrations of error correction below break even are now possible. Still, the circuits required for quantum error correction introduce significant overhead and sometimes ...
Noah Berthusen, Shi Jie Samuel Tan, Eric Huang, Daniel Gottesman   +3 more
doaj   +1 more source

A Novel Error Correction Mechanism for Energy-Efficient Cyber-Physical Systems in Smart Building

IEEE Access, 2018
Smart building is an effective solution to address the issue of energy consumption in today's cyber-physical systems (CPSs) connected world. As an important tool to collect information from a fleet of electric appliance that installed in the building ...
Ming Zhan, Jun Wu, Hong Wen, Peng Zhang
doaj   +1 more source

Diffusion‐MRI‐Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains

Advanced Science, EarlyView.
We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu, Minhui Ouyang, Shufang Tan, Jianlin Guo, Ziqin Zhang, Xuan Liu, Risheng Liu, Hao Huang   +7 more
wiley   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

VLSI single-chip (255,223) Reed-Solomon encoder with interleaver [PDF]

, 1990
The invention relates to a concatenated Reed-Solomon/convolutional encoding system consisting of a Reed-Solomon outer code and a convolutional inner code for downlink telemetry in space missions, and more particularly to a Reed-Solomon encoder with ...
Deutsch, Leslie J., Hsu, In-Shek, Reed, Irving S., Truong, Trieu-Kie   +3 more
core   +1 more source

Exact Performance of Concatenated Quantum Codes [PDF]

, 2002
When a logical qubit is protected using a quantum error-correcting code, the net effect of coding, decoherence (a physical channel acting on qubits in the codeword) and recovery can be represented exactly by an effective channel acting directly on the ...
A. M. Steane, Andrew C. Doherty, Benjamin Rahn, C. H. Bennett, C. King, D. A. Lidar, E. Knill, Hideo Mabuchi, P. W. Shor, R. Laflamme   +9 more
core   +4 more sources

HiST: Histological Images Reconstruct Tumor Spatial Transcriptomics via MultiScale Fusion Deep Learning

Advanced Science, EarlyView.
HiST, a multiscale deep learning framework, reconstructs spatially resolved gene expression profiles directly from histological images. It accurately identifies tumor regions, captures intratumoral heterogeneity, and predicts patient prognosis and immunotherapy response.
Wei Li, Dong Zhang, Eryu Peng, Shijun Shen, Hamid Alinejad‐Rokny, Yao Liu, Junke Zheng, Cizhong Jiang, Youqiong Ye   +8 more
wiley   +1 more source