Results 41 to 50 of about 65,671 (226)
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Hydrocarbon recovery by condensed rotational separation
Journal of Petroleum Exploration and Production Technology, 2012 Condensed rotational separation (CRS) is a novel method of gas–gas separation. It is based on pressure distillation at semi-cryogenic temperatures whereby one of the components is condensed, thereby forming a mist of micron-sized droplets.
H. P. Kemenade, J. Brouwers
semanticscholar +1 more source
Concentration-compactness principle for nonlocal scalar field equations with critical growth
Journal of Mathematical Analysis and Applications, 2017 The aim of this paper is to study a concentration-compactness principle for homogeneous fractional Sobolev space $\mathcal{D}^{s,2} (\mathbb{R}^N)$ for ...
João Marcos do Ó, Diego Ferraz
openaire +3 more sources
EXISTENCE OF STEADY STATES FOR THE MAXWELL–SCHRÖDINGER–POISSON SYSTEM: EXPLORING THE APPLICABILITY OF THE CONCENTRATION–COMPACTNESS PRINCIPLE [PDF]
Mathematical Models and Methods in Applied Sciences, 2013 This paper reviews recent results and open problems concerning the existence of steady states to the Maxwell–Schrödinger system. A combination of tools, proofs and results are presented in the framework of the concentration–compactness method.
Catto, Isabelle +3 more
openaire +4 more sources
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Concentration-compactness results for systems in the Heisenberg group
, 2020 . In this paper we complete the study started in [P. Pucci, L. Temperini, Existence for (p,q) critical systems in the Heisenberg group, Adv. Nonlinear Anal.
P. Pucci, Letizia Temperini
semanticscholar +1 more source