Results 41 to 50 of about 25,464 (224)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Concentration-compactness principle for nonlocal scalar field equations with critical growth

Journal of Mathematical Analysis and Applications, 2017
The aim of this paper is to study a concentration-compactness principle for homogeneous fractional Sobolev space $\mathcal{D}^{s,2} (\mathbb{R}^N)$ for ...
João Marcos do Ó, Diego Ferraz
openaire   +3 more sources

Concentration-compactness principle for Trudinger–Moser inequalities on Heisenberg groups and existence of ground state solutions [PDF]

Calculus of Variations and Partial Differential Equations, 2018
Let $\mathbb{H}^{n}=\mathbb{C}^{n}\times\mathbb{R}$ be the $n$-dimensional Heisenberg group, $Q=2n+2$ be the homogeneous dimension of $\mathbb{H}^{n}$. We extend the well-known concentration-compactness principle on finite domains in the Euclidean spaces of \ P. L. Lions to the setting of the Heisenberg group $\mathbb{H}^{n}$.
Guozhen Lu, Maochun Zhu, Jungang Li
openaire   +3 more sources

A simple derivation of BV bounds for inhomogeneous relaxation systems [PDF]

, 2014
We consider relaxation systems of transport equations with heterogeneous source terms and with boundary conditions, which limits are scalar conservation laws. Classical bounds fail in this context and in particular BV estimates.
Perthame, Benoit, Seguin, Nicolas, Tournus, Magali   +2 more
core   +2 more sources

Looping dynamics of flexible chain with internal friction at different degree of compactness

, 2015
Recently single molecule experiments have shown the importance of internal friction in biopolymer dynamics. Such studies also suggested that the internal friction although independent of solvent viscosity has strong dependence on denaturant concentration.
Chakrabarti, Rajarshi, Samanta, Nairhita
core   +2 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

EXISTENCE OF STEADY STATES FOR THE MAXWELL–SCHRÖDINGER–POISSON SYSTEM: EXPLORING THE APPLICABILITY OF THE CONCENTRATION–COMPACTNESS PRINCIPLE [PDF]

Mathematical Models and Methods in Applied Sciences, 2013
This paper reviews recent results and open problems concerning the existence of steady states to the Maxwell–Schrödinger system. A combination of tools, proofs and results are presented in the framework of the concentration–compactness method.
Catto, Isabelle, Dolbeault, Jean, Sanchez, Oscar, Soler, Juan   +3 more
openaire   +5 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

The concentration–compactness principle for Orlicz spaces and applications

Mathematische Nachrichten
AbstractIn this paper, we extend the well‐known concentration–compactness principle of P.L. Lions to Orlicz spaces. As an application, we show an existence result to some critical elliptic problem with nonstandard growth.
Julián Fernández Bonder, Analía Silva
openaire   +2 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source