Results 61 to 70 of about 25,464 (224)
Blow-up Profile of Neutron Stars in the Chandrasekhar theory
, 2019 We study the Chandrasekhar variational model for neutron stars, with or without an external potential. We prove the existence of minimizers when the attractive interaction strength $\tau$ is strictly smaller than the Chandrasekhar limit $\tau_c$ and ...
Nguyen, Dinh-Thi
core +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
, 2019 The aim of this paper is to investigate the existence, multiplicity and concentration of positive solutions for the following nonlocal system of fractional Schr\"odinger equations \begin{equation*} \left\{ \begin{array}{ll} \varepsilon^{2s} (-\Delta)^{s ...
Ambrosio, Vincenzo
core +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Journal of Differential Equations, 2002 AbstractFor a bounded domain Ω⊂R2, we establish a concentration-compactness result for the following class of “singular” Liouville equations:−Δu=eu−4π∑j=1mαjδpj in Ω where pj∈Ω, αj>0 and δpj denotes the Dirac measure with pole at point pj, j=1,…,m. Our result extends Brezis–Merle's theorem (Comm.
BARTOLUCCI, DANIELE +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Note on the concentration-compactness principle for generalized Moser-Trudinger inequalities
Open Mathematics, 2012 Abstract Let Ω ⊂ ℝn, n ≥ 2, be a bounded domain and let α < n − 1. Motivated by Theorem I.6 and Remark I.18 of [Lions P.-L., The concentration-compactness principle in the calculus of variations. The limit case. I, Rev. Mat. Iberoamericana, 1985, 1(1), 145–201] and by the results of [Černý R., Cianchi A., Hencl S., Concentration ...
openaire +3 more sources
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
The Concentration-Compactness Principle in the Calculus of Variations. The limit case, Part 1
Revista Matemática Iberoamericana, 1985 After the study made in the locally compact case for variational problems with some translation invariance, we investigate here the variational problems (with constraints) for example in \mathbb R^N where the invariance of \mathbb R^N
openaire +4 more sources