Results 141 to 150 of about 2,231,763 (313)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Effect of Ca dopant concentration on the change in properties of ZrO2 ceramics

Physical Sciences and Technology
The work is devoted to the study of effects associated with polymorphic transformations in ZrO2 ceramics stabilized by 0.1 M CaCO3, with variations in the temperature of thermal annealing.
Kuanysh Samarkhanov, Saulet Askerbekov
doaj   +1 more source

Openness, industrialization, and geographic concentration of activities in China [PDF]

Rapid development, a widening regional gap, and growing concentration of activities have characterized the Chinese economy since the reforms in the late 1970s.
Van Huffel, Christophe, Catin, Maurice, Luo, Xubei   +2 more
core  

Contrasting responses of leaf stomatal characteristics to climate change: a considerable challenge to predict carbon and water cycles

, 2017
Stomata control the cycling of water and carbon between plants and the atmosphere; however, no consistent conclusions have been drawn regarding the response of stomatal frequency to climate change.
Yan, Weiming, Zhong, Yangquanwei, Shangguan, Zhouping, Shangguan, ZP (reprint author), Inst Soil & Water Conservat, Xinong Rd 26, Yangling 712100, Shaanxi, Peoples R China.   +3 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Odor Concentration Change Coding in the Olfactory Bulb. [PDF]

eNeuro, 2019
Parabucki A, Bizer A, Morris G, Munoz AE, Bala ADS, Smear M, Shusterman R.   +6 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Geographical Analysis of US Green Sector Industry Concentration

This paper analyzes the geographic distribution of “green energy” sector clustering in the lower 48 United States using recent developments in industry concentration analysis.
English, Burton C., Lambert, Dayton M., Wilcox, Michael D., Menard, R. Jamey, Register, D. Lane, Jensen, Kimberly L.   +5 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Socially Beneficial Mergers: A New Class of Concentration Indices [PDF]

The prominent Herfindahl-Hirschman index (HHI), yields a higher concentration level in response to any merger between firms, implying that any merger will decrease the social welfare. Although HHI is used by the Anti-trust Division of the U.S. Department
Brett Katzman, Nejat Anbarci
core