Results 191 to 200 of about 2,231,763 (313)

Comparison of Changes in Biomarkers With Changes in Endoscopic Scores in Patients With Ulcerative Colitis: A Single-Center, Retrospective, Observational Study. [PDF]

JGH Open
Yamada Y, Ishida N, Takebe T, Takahashi K, Asai Y, Yamade M, Iwaizumi M, Hamaya Y, Yamada T, Osawa S, Sugimoto K.   +10 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Ultra-Rapid Lispro Has an Improved Pharmacokinetic Profile for Exercise Compared With Lispro, Resulting in Less Exercise-Associated Hypoglycemia in Adults With Type 1 Diabetes on Open-Loop Continuous Subcutaneous Insulin Infusion. [PDF]

Diabetes Care
Leohr JK, Abitbol A, Turner LV, Smith LaBell E, Ghosh A, Coutant DE, Riddell MC.   +6 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Spray Drying of Aonla Juice Mixed With Giloy Extract for Process Optimization, Product Development and Characterization. [PDF]

Food Sci Nutr
Jhally G, Sharma SR, Kaur K, Alam MS, Rani S, Mittal TC, Chavan P, Jaiswal AK.   +7 more
europepmc   +1 more source

Sudden significant total protein concentration change: not an analytical problem. [PDF]

J Clin Lab Anal, 2011
Dimeski G, Wood P.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Impact assessment of climate change on wheat yield in Gujarat using CERES- wheat model

Journal of Agrometeorology, 2007
VYAS PANDEY, H. R. PATEL, V. J. PATEL
doaj   +1 more source

Case Report: The "delta effect": when endocrine pathology hides in plain sight. [PDF]

Front Endocrinol (Lausanne)
Voets PJGM.
europepmc   +1 more source