Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
New Approach to Determine the Activity Concentration Index in Cements, Fly Ashes, and Slags on the Basis of Their Chemical Composition. [PDF]
Materials (Basel), 2023 Caño A +4 more
europepmc +1 more source
IDDF2018-ABS-0208 Faecal HSF2 concentration maybe used as an evaluation index for predicting the mucosal healing of uc [PDF]
, 2018 Junkun Niu
openalex +1 more source
Spatial Point Pattern Analysis and Industry Concentration [PDF]
Traditional measures of spatial industry concentration are restricted to given areal units. They do not make allowance for the fact that concentration may be differently pronounced at various geographical levels. Methods of spatial point pattern analysis
Hans-Friedrich Eckey +2 more
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
When the technical is also normative: a critical assessment of measuring health inequalities using the concentration index-based indices. [PDF]
Popul Health Metr, 2022 Contoyannis P, Hurley J, Walli-Attaei M.
europepmc +1 more source
Socially Beneficial Mergers: A New Class of Concentration Indices [PDF]
The prominent Herfindahl-Hirschman index (HHI), yields a higher concentration level in response to any merger between firms, implying that any merger will decrease the social welfare. Although HHI is used by the Anti-trust Division of the U.S. Department
Brett Katzman, Nejat Anbarci
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Equity of Social Health Insurance Coverage for Migrants in Thailand: A Concentration Index Analysis. [PDF]
Int J Environ Res Public Health, 2021 Piancharoen P +2 more
europepmc +1 more source