Results 231 to 240 of about 2,408,039 (303)

A cost-effective image-based machine learning framework for automating active iron estimation in Peach (Prunus persica (L.) Batsch) Leaves. [PDF]

Sci Rep
Imani A, Sepehr E, Rengel Z, Hajizade N.
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Socioeconomic inequalities in institutional delivery in Ethiopia: a decomposition analysis of EDHS data (2011-2019). [PDF]

BMC Health Serv Res
Tsega Y, Endawkie A, Kebede SD, Abera KM, Abeje ET, Enyew EB, Daba C, Asmare L, Bayou FD, Arefaynie M, Mohammed A, Tareke AA, Keleb A, Kebede N.   +13 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Education-Based Inequality in Edentulism and Functional Dentition Among Older Brazilian Adults: A Study Covering a Period of 20 Years. [PDF]

Int J Dent
Fonseca MLV, Gomes VE, Chamane LS, da Cruz CAG, Silva MLDN, Francisco ALG, Chalub LLFH, Ferreira RC.   +7 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Comparing disparities in geographic proximity to exercise-based cardiac rehabilitation before and after decentralisation of services: a repeated cross-sectional study using individual-level register data. [PDF]

Int J Equity Health
Bihrmann K, Zwisler AD, Søndergaard H, Svendsen MLO, Ersbøll AK.   +4 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Metals and Geochemical Indexes in Sediments of a Karstic Coastal Tropical Lagoon: Evaluating the Ecological Risk in Celestun, Yucatan, Mexico. [PDF]

Bull Environ Contam Toxicol
Arcega-Cabrera F, León-Aguirre K, Lamas-Cosío E, Oceguera-Vargas I.   +3 more
europepmc   +1 more source