Results 241 to 250 of about 2,408,039 (303)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Effect of combined ustekinumab and partial enteral nutrition on clinical and nutritional outcomes in Crohn's disease. [PDF]

Medicine (Baltimore)
Wang S, Yang Y, Hu X, Liu P, Xu W, Zhou Y, Lin P, Yuan K, Lin T, Ding B.   +9 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Analysing the vulnerability of mangrove forest by vegetation health assessment: a study of Indian sundarbans deltaic region. [PDF]

Sci Rep
Ghosh A, Mondal P.
europepmc   +1 more source

Urinary equol concentration, body composition, and lifestyle factors were associated with bone mass in young women. [PDF]

BMC Womens Health
Hanano H, Aoki T, Sasaki S, Fujikawa H, Oishi K, Yamamoto Y, Yamaguchi H, Mori T, Ishii K.   +8 more
europepmc   +1 more source

Investigation of the effects of aerators in reducing cavitation damage on spillways using two-phase numerical modeling. [PDF]

Sci Rep
Bagherzadeh S, Ghaeini-Hessaroeyeh M, Fadaei-Kermani E.   +2 more
europepmc   +1 more source

Wealth-related inequalities in HIV testing and counselling during antenatal care among reproductive age women in Ethiopia: a decomposition analysis. [PDF]

BMJ Public Health
Alemu SB, Ebrahim AB, Belay A, Yizengaw MT, Alemu MB.   +4 more
europepmc   +1 more source

Socioeconomic inequality and its drivers in unmet needs for family planning in Kenya. [PDF]

BMC Public Health
Wakibi SN.
europepmc   +1 more source

A study on concentration index and degree of concentration in Tokyo.

Journal of Geography (Chigaku Zasshi), 1990
openaire   +2 more sources