Results 261 to 270 of about 2,426,264 (355)

Analyzing Trends in Socioeconomic Disparities in Oral Health Services: A concentration index decomposition approach (2005- 2021) [PDF]

Jie Liu, Xiangyu Huang, Weihua Fan, Zhi’e Liu, Shaohong Huang, Yuandong Qin   +5 more
openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Construction, validation, and nitrogen nutrition diagnosis of a critical nitrogen concentration model for cotton. [PDF]

Front Plant Sci
Qin Y, Feng W, Chen J, Zheng C, Leng Y, Wang L, Zhang L, Nie T.   +7 more
europepmc   +1 more source

Evaluation of the daily rainfall concentration index in Brazil

Álvaro José Back, Gabriel da Silva Souza, ́Sérgio Luciano Galatto   +2 more
openalex   +2 more sources

MOESM1 of Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: a prospective observational study

, 2017
Isabel Castro-Orós, Pilar Irún Irún, Jorge J Cebolla, Victor Rodriguez-Sureda, Miguel Angel Mallén, María Pueyo, Pilar Mozas, Carmen Domínguez, Miguel Pocoví   +8 more
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

P91 GREEN TEA EXTRACT REDUCES LIPID PROFILE, PERCENTAGE OF AORTIC AUGMENTATION INDEX AND INCREASES SOLUBLE RAGE CONCENTRATIONS IN NORMOTENSIVE PATIENTS WITH TYPE 2 DIABETES MELLITUS: A RANDOMIZED, DOUBLE-BLINDED, AND PLACEBO- CONTROLLED TRIAL

, 2017
Fernando Grover Páez, Patricia Quezada Fernandez, Mariana Rodriguez de la Cerda, David Müller, Jhonatan Trujillo Quiroz, Walter Ángel Trujillo-Rangel, Marycruz Barocio Pantoja   +6 more
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source