Results 91 to 100 of about 4,079,422 (304)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Beef Cattle Large Commodity Chain in East Java: Market Structure and Performance Analysis
Agriekonomika, 2019 Smallholder farmers dominate in the beef cattle industry (98%), and the contribution of large farmers is only 2%. National beef cattle industry could not fulfill domestic demand.
Andrie Kisroh Sunyigono
doaj +1 more source
Experimental study of cross-stream mixing in a cylindrical duct [PDF]
An experimental investigation of cross stream injection and mixing was conducted with application to a low NO sub x combustor for the High Speed Civil Transport (HSCT).
Holdeman, J. D. +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
concentration distribution ratio
, 2008 Citation: 'concentration distribution ratio' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.C01225 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
RESTAURANT CONCENTRATION IN LOUISIANA [PDF]
Growth of the franchise restaurant industry and merger activity among restaurants raise questions concerning concentration in the Louisiana restaurant industry.
Dennis, Winston, Schupp, Alvin R.
core +1 more source
The Mass-Concentration Relation and the Stellar-to-Halo Mass Ratio in the CFHT Stripe 82 Survey
, 2017 We present a new measurement of the mass-concentration relation and the stellar-to-halo mass ratio over the halo mass range $5\times 10^{12}$ to $2\times 10^{14}M_{\odot}$. To achieve this, we use weak lensing measurements from the CFHT Stripe 82 Survey (
Charbonnier, Aldée +10 more
core +3 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source