Results 121 to 130 of about 4,079,422 (304)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Strain Concentration Ratio Analysis of Different Waterproofing Materials during Concrete Crack Movement. [PDF]

Materials (Basel), 2021
Oh KH, Kim SY.
europepmc   +1 more source

Studies on temperature dependent semiconductor to metal transitions in ZnO thin films sparsely doped with Al

, 2012
For a detailed study on the semiconductor to metal transition (SMT) in ZnO thin films doped with Al in the concentration range from 0.02 to 2%, we grew these films on (0001) sapphire substrates using sequential pulsed laser deposition.
Ajimsha, R. S., Bose, A., Das, Amit K., Joshi, S. C., Kukreja, L. M., Misra, P., Phase, D. M.   +6 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Small pilot study of ultra-high pressure reverse osmosis technology for treating landfill leachate in Northwest China

Gongye shui chuli
Landfill leachate has high COD, ammonia nitrogen and conductivity, these complex pollution characteristics make the reverse osmosis treatment load too high, which further leads to the decrease of membrane performance and membrane permeate flux.
ZHANG Huixiang, ZHANG Xuemin, SUN Sanxiang, LI Li   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Structure - Conduct - Performance paradigm revisited: an empirical analysis for Vietnamese firms

Journal of International Economics and Management, 2014
The Structure-Conduct-Performance (SCP) paradigm became the dominant framework for empirical work in Industrial Organization starting from the early 1950s.1 There have been a large number of empirical researches in the literature examining the SCP ...
Thuy Anh Tu, Thi Thanh Binh Dinh, Binh Duong Nguyen, Viet Duong Nguyen   +3 more
doaj  

Performance Simulation and Optimization of Cylindrical Mirror-Spliced Parabolic Trough Solar Collector

Applied Sciences
This paper proposes a new type of solar trough collector with a spliced cylindrical mirror and develops a new ray-tracing method to predict and optimize its performance.
Bowen Liu, Vian Mbabazi, Weidong Huang
doaj   +1 more source

Association between urinary N-acetyl-β-glucosaminidase activity-urinary creatinine concentration ratio and risk of disability and all-cause mortality. [PDF]

PLoS One, 2022
Tanaka SI, Fujioka Y, Tsujino T, Ishida T, Hirata KI.   +4 more
europepmc   +1 more source