Results 211 to 220 of about 205,694 (360)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Directionality bias in T/A cloning. [PDF]

MicroPubl Biol
Dountcheva V, Bubulya A, Rouhana L.
europepmc   +1 more source

Luminescent Solar Concentrators Based on Renewable Polyester Matrices [PDF]

, 2018
Tristan A. Geervliet, Ionela Gavrila, Giuseppe Iasilli, Francesco Picchioni, Andrea Pucci   +4 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Investigations on Organic Push-Pull Dyes for Luminescent Solar Concentrator Applications. [PDF]

ACS Appl Opt Mater
Bondi R, Arrigo A, Cela E, Vaccaro L, Marrocchi A, Marchini F, Pisello AL, Nastasi F, Latterini L.   +8 more
europepmc   +1 more source

MOESM1 of Effect of sugarcane fiber digestibility, conservation method and concentrate level on the ruminal ecosystem of beef cattle

, 2017
Johnny Souza, Dannylo Sousa, Bruno de Souza Mesquita, Lígia Garcia Mesquita, Luís Felipe Prada e Silva   +4 more
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Hybrid Perovskite-Photovoltaic and Solar-Thermal Harvesting. [PDF]

Adv Sci (Weinh)
Huang G, Arya PH, Ritzer DB, Alati NA, Abdollahi Nejand B, Paetzold UW, Richards BS.   +6 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hypophosphite-assisted ball milling enables broadband self-trapped exciton emission in copper halides for self-powered smart windows. [PDF]

RSC Adv
Xie Y, Zhang J, Zhang B, Liu J, Ding J, Gao T, Chen A, Wang W, Wang Y, Wang A.   +9 more
europepmc   +1 more source