Results 291 to 300 of about 205,694 (360)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Uli-epic: profiling RNA modifications from ultra-low input samples. [PDF]

open access: yesGenome Biol
He W   +9 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Potassium-Hydroxide-Based Extraction of Nicotinamide Adenine Dinucleotides from Biological Samples Offers Accurate Assessment of Intracellular Redox Status. [PDF]

open access: yesInt J Mol Sci
Faludi T   +11 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Hybrid Metasurface for On-Chip Enrichment and Quantification of Biological Samples. [PDF]

open access: yesACS Appl Mater Interfaces
Zhang Q   +7 more
europepmc   +1 more source

Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1

open access: yes
Leonard-Booker C   +6 more
europepmc   +1 more source

The adaptive nature of the foam proteome produced by Mahanarva spectabilis (Hemiptera: Cercopidae) when infesting forage grasses with different levels of antibiosis-type resistance. [PDF]

open access: yesSci Rep
José Rinaldi A   +7 more
europepmc   +1 more source

Touch Piezoelectric Sensor for Vibration Intensity Testing. [PDF]

open access: yesSensors (Basel)
Rotmanas A   +3 more
europepmc   +1 more source

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