Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The influence of self-concept on prosocial behavior in delinquent juveniles: a chain mediation analysis involving belief in a just world and self-control. [PDF]
Front PsycholTeng H, Guo J, Sheng H, Li Y.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The Mediating Role of Spiritual Intelligence in the Relationships Among Well-Being, Professional Self-Concept and Empathy Among Nurses. [PDF]
Nurs OpenRayan A +5 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
"Three Augustinian Clerics Die": Navigating a Campus\u27s Experience During a Global Pandemic
When the 1918 influenza pandemic swept through Pennsylvania, Villanova was a small, developing campus consisting of a prep academy for boys, a seminary, and a college for lay people.
Cholowinski, Jenna
core
From Angiosome to Woundosome: An Interdisciplinary Approach to Personalized Revascularization in Chronic Limb-Threatening Ischemia. [PDF]
Diagnostics (Basel)Popitiu MI +7 more
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
More Than a Peanut Inventor: George Washington Carver and the Natural Enviornment
George Washington Carver is the most famous Black scholar in American history. Still, he has yet to receive fastidious investigation through a Black Studies lens--the list of full-length academic inquiries into Carver remains short. Linda O. McMurry\u27s
Smith, Isaac
core
When Cronbach's alpha does (not) indicate the reliability of domain-specific knowledge tests and why. [PDF]
Front PsycholZitzmann S, Orona GA.
europepmc +1 more source