Results 41 to 50 of about 1,419,473 (306)
Koža i ObućaThe footwear industry is constantly evolving, with sustainability and the integration of digital technologies among the most important trends. Additive manufacturing, popularly known as 3D printing, is an advanced technology that is significantly ...
Sara Stojko +2 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Awareness of the concept of universal design in design education
, 2012 Design professions, principally architecture, interior architecture, landscape design, industrial design and graphic design have to attach importance to create environments and products that derives an accessible design by all user groups.
Güneş, Elif +2 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Nature and role of intermediate representation (IR) in the design process [PDF]
, 2005 This paper aims to show the key role of the intermediate representations (IR) in the design process and especially in the car design process. For a better understanding of the concept of design, which is by nature conceptual, we propose to study the ...
AOUSSAT, Améziane +2 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Digital information support for concept design
, 2010 This paper outlines the issues in effective utilisation of digital resources in conceptual design. Access to appropriate information acts as stimuli and can lead to better substantiated concepts.
Wodehouse, Andrew, Ion, William
core +1 more source
Jurnal Pengabdian dan Edukasi Sekolah, 2021 Konsep pembagian pecahan masih merupakan konsep yang sulit bagi sebagian besar siswa. Banyak siswa SD maupun SMP belum dapat menulis dengan benar rumus pembagian pecahan .
Firman Pangaribuan +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source