Results 211 to 220 of about 1,328,254 (307)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Associations of the Zhejiang University (ZJU) index with reproductive outcomes in women with polyendocrine metabolic ovarian syndrome: a <i>post-hoc</i> analysis. [PDF]

Front Nutr
Liu Y, Gong Y, Ge H, Zhu M, Yu H, Feng J, Hu X, He H, Gao J, Wu X.   +9 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Respiratory morbidity at age 4 across COVID-19 and pre-pandemic birth cohorts: the role of atopic risk. [PDF]

Eur J Pediatr
Kamar A, Mandelberg A, NatalyRosenfeld, Tasher D, Michleson M, Meridor Eisner A, Ovadia A, Shen Cohen Y, Manor A, Armoni Domany K.   +9 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A population-based study of the co-occurrence of hypospadias and congenital heart defects among boys conceived with in vitro fertilization†. [PDF]

Hum Reprod
Richard MA, Luke B, Jaime E, Fisher SC, Betancourt D, Yazdy MM, Stone SL, Forestieri NE, Wantman E, Baker VL, Eisenberg ML, Williams C, Sutcliffe AG, Lupo PJ.   +13 more
europepmc   +1 more source

Conception

, 2011
La Rochebrochard, Elise de, de La Rochebrochard, Elise   +1 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Delayed conception or sildenafil prevents endothelial dysfunction in pregnant rats after renal ischemia-reperfusion. [PDF]

Am J Physiol Renal Physiol
Moronge D, Ayulo V, Mellott E, Godley-Boswell H, Mohamed R, Sullivan JC, Faulkner JL.   +6 more
europepmc   +1 more source