Results 81 to 90 of about 23,355,197 (299)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Incorporating business requirements and constraints in database conceptual models
, 2004 Entity relationship (ER) approach is predominantly used for conceptual modelling of database systems in terms of entities and their relationships. The approach does not provide sufficient support for incorporating business constraints and their impact on
Khan, Khaled M. +2 more
core
Urmson J. O. Polymorphous concepts / trans. from Engl. by A. V. Nekhaev, I. N. Nekhaeva
Омский научный вестник: Серия "Общество. История. Современность"The article attempts to clarify the criteria for Ryle’s class of polymorphous concepts. Ryle calls paradigmatic examples of the class such concepts as working and thinking.
A. V. Nekhaev, I. N. Nekhaeva
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Loose Constitutivity and Armchair Philosophy
Studia Philosophica Estonica, 2009 Standard philosophical methodology which proceeds by appeal to intuitions accessible "from the armchair" has come under criticism on the basis of empirical work indicating unanticipated variability of such intuitions. Loose constitutivity---the idea that
Jonathan M. Weinberg, Stephen J. Crowley
doaj
Digital Studies, 2012 : When one needs to apply computer-assisted conceptual analyses of philosophical texts beyond their linguistic dimension, statistic macro-textual approaches have given appealing results but remain limited.
Jean Danis, Jean-Guy Meunier
doaj +1 more source
Operant variability: A conceptual analysis [PDF]
The Behavior Analyst, 2012 Some researchers claim that variability is an operant dimension of behavior. The present paper reviews the concept of operant behavior and emphasizes that differentiation is the behavioral process that demonstrates an operant relation. Differentiation is conceived as change in the overlap between two probability distributions: the distribution of ...
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Entropy, 2019 Since its inception, the concept of entropy has been known under a variety of guises and been used in an increasing number of contexts, achieving an almost rock star-like status in both the sciences and popular culture.
Rocco Gaudenzi
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source