Results 71 to 80 of about 145,535 (283)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A conceptual model for advanced/metastatic gastric or gastroesophageal junction cancer: a review of qualitative studies and results from patient interviews

BMC Cancer
Background Despite approvals of new first-line immunotherapies for advanced/metastatic gastric cancer/gastroesophageal junction cancer (aGC/GEJC), patients’ median survival is around 14 months and their health-related quality of life (HRQoL) is affected ...
France Ginchereau Sowell, Thom de Milliano, Keri J. S. Brady, Ginamarie Foglia, Medha Sasane, Samira Bensfia, Matthew Reaney   +6 more
doaj   +1 more source

Integration of biosafety surveillance through Biosafety Surveillance Conceptual Data Model

Biosafety and Health, 2019
The global movement of people and goods has increased the risk of biosecurity threats and their potential to induce large economic, social, and environmental harm.
Songwang Wang, Yangfei Li, Qiang Chen, Xiaoyu Feng, Xiju Shi, Ying Huang, Li Mei, Wei Li, Haizhou Liu, Xiaopeng Qi, Di Liu   +10 more
doaj   +1 more source

A Conceptual Framework for Analyzing Social-Ecological Models of Emerging Infectious Diseases [PDF]

, 2014
Unraveling mechanisms underlying new and reemerging infectious diseases (EID) requires exploring complex interactions within and among coupled natural and human (CNH) systems. To address this difficult scientific problem, we need to understand how transformations in social-ecological systems caused by multifaceted interactions with anthropogenic ...
Finucane, Melissa L., Fox, Jefferson, Saksena, Sumeet, Spencer, James H.   +3 more
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The conceptual relevance of assessment measures in patients with mild/mild‐moderate Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction This study aims to evaluate the conceptual relevance of four measures of disease activity in patients with mild/mild‐moderate Alzheimer's disease (AD): (1) the Alzheimer's Disease Assessment Scale–Cognitive Subscale; (2) the Alzheimer's ...
Ann Hartry, Natalie V.J. Aldhouse, Tamara Al‐Zubeidi, Myrlene Sanon, Richard G. Stefanacci, Sarah L. Knight   +5 more
doaj   +1 more source

An evidence-based conceptual framework of healthy cooking

Preventive Medicine Reports, 2016
Eating out of the home has been positively associated with body weight, obesity, and poor diet quality. While cooking at home has declined steadily over the last several decades, the benefits of home cooking have gained attention in recent years and many
Margaret Raber, Joya Chandra, Mudita Upadhyaya, Vanessa Schick, Larkin L. Strong, Casey Durand, Shreela Sharma   +6 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

[Genetically determined diseases of the hip joint (a conceptual model)].

Ortopediia travmatologiia i protezirovanie, 1990
The authors consider the problem of pathology of the hip joint from the point of view of the conception "Dysplasia-coxarthrosis". A single system of the ideas concerning dysplastis pathology is presented, which will allow to unify the methods of diagnosis and treatment of dysplasia of the hip joint in children, adolescents and adults with the aim of ...
B I, Simenach, Iu G, Polozov, E Ia, Pankov, S D, Shevchenko   +3 more
openaire   +1 more source