A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso+5 more
wiley +1 more source
Conceptual framework as a guide to choose appropriate imputation method for missing values in a clinical structured dataset. [PDF]
Afkanpour M+3 more
europepmc +1 more source
Hydrogel‐Based Capacitive Sensor Model for Ammonium Monitoring in Aquaculture
Traditional techniques for monitoring aquaculture water quality, particularly ammonium levels, harm fish. This work presents a novel capacitive sensor with an ionic hydrogel transducer to monitor ammonium concentration in real time based on the ammonium‐induced hydrogel dissociation and osmotic pressure. Monitoring aquaculture water quality, especially
Mohammad Mirzaee+3 more
wiley +1 more source
Visualizing user demands through storyboarding in the mHealth app development for pregnant women: a conceptual framework. [PDF]
Yu X+8 more
europepmc +1 more source
Bridging Nature and Technology: A Perspective on Role of Machine Learning in Bioinspired Ceramics
Machine learning (ML) is revolutionizing the development of bioinspired ceramics. This article investigates how ML can be used to design new ceramic materials with exceptional performance, inspired by the structures found in nature. The research highlights how ML can predict material properties, optimize designs, and create advanced models to unlock a ...
Hamidreza Yazdani Sarvestani+2 more
wiley +1 more source
A conceptual framework for soft tissue management of transdermal bone-anchored implants in extremity prostheses. [PDF]
Wordsworth M+4 more
europepmc +1 more source
The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez+5 more
wiley +1 more source
Meditation and interoception: a conceptual framework for the narrative and experiential self. [PDF]
Gibson JE.
europepmc +1 more source
The Metapopulation Bridge to Macroevolutionary Speciation Rates: A Conceptual Framework and Empirical Test. [PDF]
Januario M, Pinsky ML, Rabosky DL.
europepmc +1 more source
The impact of climate change on child nutrition in Indonesia: a conceptual framework and scoping review of the available evidence. [PDF]
Colozza D+7 more
europepmc +1 more source