Results 51 to 60 of about 146,208 (262)
Conceptualizando América. Historia de los conceptos e ideas fuera de lugar
Nuevo mundo - Mundos Nuevos, 2012 In this essay I speak in favour of a meta-metodology of historical research which is based upon the general principles of conceptual history. My hypothesis is that conceptual history is a theoretical and methodological resource that improves the ...
Ángel Octavio Álvarez Solís
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Algorithms and conceptual history
Revista de Filosofía de la Universidad de Costa RicaThis essay explores the theoretical questions emerging from the proliferation of digitally mediated forms of social intercourse and their impact on the modern constellation of political and social concepts. While several disciplines have long since begun to address the impact of digital technology on their objects of study, an inquiry into how the ...
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Michael Stolleis ou le fin mot de l’histoire
Clio@ThemisIn this short text, I gather personal memories of Michaël Stolleis, who headed the Max Planck Institut in Frankfurt am Main when I visited as a PhD student, in 2008.
Pierre Thévenin
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Beyond Mood and Atmosphere: a Conceptual History of the Term Stimmung. [PDF]
Philosophia (Ramat Gan), 2021 Thonhauser G.
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Idiopathic plasmacytic lymphadenopathy: A conceptual history along with a translation of the original Japanese article published in 1980. [PDF]
J Clin Exp Hematop, 2022 Takeuchi K.
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source