Results 61 to 70 of about 3,563,997 (305)
IEEE Access, 2016 For the complex semantic features of objects in a geological map, maintaining a hierarchy between different geological objects is a big challenge when automatically generalizing the geological map.
Junqiang Zhang, Chonglong Wu, Lizhe Wang
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How Conceptual Are Semantic Maps?
Linguistic Discovery, 2010 The question addressed in this paper is whether (and to what extent) a semantic map aimed at representing the multifunctionality of a given construction (or set of constructions) in discourse can be thought of as endowed with conceptual reality. To be considered as a mental representa-tion that is essentially similar in all human brains, such a map ...
openaire +5 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
THE CONCEPTUAL MAP SOLUTION TO THE PARADOX OF CONCEPTUAL ANALYSIS
IJRDO- Journal of Educational Research, 2023 Why do a conceptual analysis on a word that we already know how to use? Marilyn Strathern provides some information on garden cities and suburbs which suggests a novel solution to me.
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Chemistry in high school having the ‘detergent’ as a motivating
Semina: Ciências Exatas e Tecnológicas, 2003 The present work was developed with the objective of associating the teaching of some concepts of chemistry with the daily routine of High School students.
Antonio Martins +5 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source