Results 91 to 100 of about 21,646,523 (374)

Parsimonious numerical modelling of deep geothermal reservoirs [PDF]

, 2015
Numerical modelling has been undertaken to help improve understanding of a deep geothermal system being considered for development in the vicinity of Eastgate (Weardale, County Durham, UK).
Fairs, Tim H., Parkin, Geoff, Younger, Paul   +2 more
core   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Conceptual modelling of human resource evaluation process

MATEC Web of Conferences, 2017
Taking into account the highly diverse tasks which employees have to fulfil due to complex requirements of nowadays consumers, the human resource within an enterprise has become a strategic element for developing and exploiting products which meet the ...
Negoiţă Doina Olivia, Purcărea Anca Alexandra, Dumitrescu Andreea, Torp Andronicus   +3 more
doaj   +1 more source

Conceptual Modelling and The Quality of Ontologies: Endurantism Vs. Perdurantism

, 2012
Ontologies are key enablers for sharing precise and machine-understandable semantics among different applications and parties. Yet, for ontologies to meet these expectations, their quality must be of a good standard.
Al Asswad, Mark Lycett, Mohammad Mourhaf, Mutaz M Al-Debei, Sergio De Cesare   +4 more
core   +1 more source

Requirements modelling and formal analysis using graph operations [PDF]

, 2006
The increasing complexity of enterprise systems requires a more advanced analysis of the representation of services expected than is currently possible.
Abrial J-R, B. Kamsu-Foguem, Baget J-F, Berio G, Bray K, Chung L, Diallo D, Ehrig H, Fox MS, Genest D, Grady J, Harel D, Hermosillo Worley J, Hoare CAR, Kamsu Foguem B, Kosanke K, Manna Z, Martin JN, Monin J-F, Robertson S, Shiu S, Sowa JF, Sowa JF, Spivey JM, Sutcliffe A, V. Chapurlat, Vernadat FB, Watson I, Young R   +28 more
core   +3 more sources

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Building a shared representation of the landscape as a socio-ecological system and visualizing the challenges of CSA. P112 [PDF]

, 2015
Climate threats exacerbate issues of natural resource management in rural landscapes, namely water, forest and agricultural land. In order to consistently address these issues, we highlight the usefulness of a joint vision of the landscape where the ...
Aguilar, Teresa, Devisscher, Tahia, Fallot, Abigaïl, Le Coq, Jean-François, Salinas, Julio Cesar, Vides-Almonacid, Roberto   +5 more
core  

Towards an Ontological Modelling of Preference Relations [PDF]

, 2018
Preference relations are intensively studied in Economics, but they are also approached in AI, Knowledge Representation, and Conceptual Modelling, as they provide a key concept in a variety of domains of application. In this
AS Rao, B Russell, C List, D Porello, D Porello, D Porello, F Dietrich, F Dietrich, F MacBride, G Guizzardi, GE Moore, J Neumann Von, J Parsons, JE Roemer, M Bratman, N Guarino, P Gärdenfors, S Borgo, V Ottonelli   +18 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source