Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
RISE: A CONCEPTUAL MODEL OF INTEGRATED AND RESTORATIVE ELDER ABUSE AND SELF-NEGLECT INTERVENTION
, 2023 David Burnes +5 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Conceptual Model of Seasonal Flooded Forest Management (Pa Bung-Pa Tham Management, PBPTM) by Community-Based Management for Lower Wetland Area of Mun River in Northeast Thailand [PDF]
, 2012 Phassakon Nuntapanic +2 more
openalex +1 more source
Development of a minimalist conceptual numerical model for flood forecasting and management under GIS environment [PDF]
, 2020 Mustapha Rabie Boudani +3 more
openalex +1 more source
Sustaining Trade during COVID-19 Pandemic: Establishing a Conceptual Model Including COVID-19 Impact [PDF]
, 2021 Nashwan M. A. Saif +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Linking Supply Chain Performance, Supply Chain Resilience, and Organizational Recovery Capability: A Proposed Conceptual Model [PDF]
Kok Beng Loh, Cheng Ling Tan
openalex +1 more source
A NEW GENERAL CONCEPTUAL APPROACH TO MODELING THE LIVESTOCK SECTOR: AN APPLICATION TO THE JAPANESE SWINE-PORK SECTOR [PDF]
, 1998 Jacinto F. Fabiosa +3 more
openalex +1 more source