Results 131 to 140 of about 21,646,523 (374)

A CAD-BASED CONCEPTUAL METHOD FOR SKULL PROSTHESIS MODELLING

open access: yesFacta Universitatis. Series: Mechanical Engineering, 2018
The geometric modeling of a personalized part of the tissue built according to individual morphology is an essential requirement in anatomic prosthesis.
Marcelo Rudek   +4 more
doaj   +1 more source

Choice and judgement in developing models for health technology assessment; a qualitative study [PDF]

open access: yes
Introduction: The role of models in supporting health policy decisions is reliant on model credibility. Credibility is fundamentally determined by the choices and judgements that people make in the process of developing a model.
Chilcott, J   +5 more
core  

A layered view model for XML with conceptual and logical extensions, and its applications [PDF]

open access: yes, 2006
University of Technology, Sydney. Faculty of Information Technology.EXtensible Markup Language (XML) is becoming the dominant standard for storing, describing and interchanging data among various Enterprises Information Systems (EIS), web repositories ...
Rajagopalapillai, R
core  

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

open access: yesMolecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren   +4 more
wiley   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

BIM-Enabled Conceptual Modelling and Representation of Building Circulation

open access: yesInternational Journal of Advanced Robotic Systems, 2014
This paper describes how a building information modelling (BIM)-based approach for building circulation enables us to change the process of building design in terms of its computational representation and processes, focusing on the conceptual modelling ...
Jin Kook Lee, Mi Jeong Kim
doaj   +1 more source

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