Results 161 to 170 of about 67,277 (288)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

A structural framework for fire and explosion risk in EFRTs: empirical validation using EFA, CFA, and path analysis. [PDF]

Sci Rep
Moshashaei P, Akbarzadeh O, Asghari-Jafarabadi M, Khazini L, Alizadeh SS.   +4 more
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Geospatial modelling for zoonotic disease hotspot identification within a one health framework: a systematic review. [PDF]

One Health Outlook
Nyengere J, Mbewe W, Malalu L, Tholo H, Njala AL, Sembo T, Kumpolota SW, Mvula RL, Chisenga C, Kanyika-Mbewe C, Maluwa A, Eregno FE.   +11 more
europepmc   +1 more source

Sub-Quantum Conceptual Computing Model Based on Semantic Fields and Nonlinear Contextual Dynamics. (IEEE)

Yoon A Limsuwan
openalex   +1 more source

Conceptual Basis for Forming the Competitive Resource Model in Kazakhstan

, 2020
Elvira Buitek, Zhanar Yeszhanova
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Conceptual Model Regarding the Impact of Scarcity on Concert Tickets that Makes Panic Buying Behavior in Indonesia Citizens after Covid-19 Pandemic

, 2022
Amira Putri Mardiana icebgc, Budhi Haryanto icebgc   +1 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Determinants, Pathways, and Outcomes of Health Literacy in India: A System Dynamics Modelling Study. [PDF]

Cureus
B A, Hassan F, Jaison A.
europepmc   +1 more source