Results 61 to 70 of about 67,277 (288)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Conceptual modelling for life sciences based on systemist foundations. [PDF]
BMC Bioinformatics, 2023 Lukyanenko R, Storey VC, Pastor O.
europepmc +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Conceptual models in the field of library catalogues
Knjižnica, 2000 The publishing world is changing quickly and so must also bibliographic control. It is tirne to re-examine cataloguing rules and MARC formats. This can be done by the method of conceptual modelling.
Marija Petek
doaj +1 more source
Conceptual Modelling of Two Large-Scale Mine Water Geothermal Energy Schemes: Felling, Gateshead, UK. [PDF]
Int J Environ Res Public Health, 2022 Banks D, Steven J, Black A, Naismith J.
europepmc +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Applications of Modelling and Simulation, 2021 Allocation of funds is one of the most important functions of the health care authorities. Performance of this function has implications not only for the macro-level health care system but also for individual patients whose wait times for medical ...
Alexei Botchkarev
doaj
Conceptual Foundations of Modelling of Innovative Production Projects
Proceedings of the International Conference on Applied Innovations in IT, 2015 At the moment there is a lack of methodological approaches to formalization of management of innovative projects relating to production systems, as well as to adaptation and practical use of the existing approaches.
Leonid Mylnikov
doaj +1 more source