Results 81 to 90 of about 21,646,523 (374)

Logics for Conceptual Data Modelling: A Review [PDF]

Transactions on Graph Data and Knowledge
Information modelling for databases and object-oriented information systems avails of conceptual data modelling languages such as EER and UML Class Diagrams.
Fillottrani, Pablo R., Keet, C. Maria
doaj   +1 more source

Temporalising OWL 2 QL [PDF]

, 2013
We design a temporal description logic, TQL, that extends the standard ontology language OWL2QL, provides basic means for temporal conceptual modelling and ensures first-order rewritability of conjunctive queries for suitably defined data instances with ...
Artale, A., Kontchakov, Roman, Wolter, F., Zakharyaschev, Michael   +3 more
core   +1 more source

Design diversity: an update from research on reliability modelling [PDF]

, 2001
Diversity between redundant subsystems is, in various forms, a common design approach for improving system dependability. Its value in the case of software-based systems is still controversial. This paper gives an overview of reliability modelling work
B Littlewood, B Littlewood, B Littlewood, B Littlewood, DE Eckhardt, JC Knight, L Hatton, P Popov, P Popov, P Popov   +9 more
core   +2 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Towards a unified conceptual model representation [PDF]

, 2007
A good documentation or representation is important for communicating simulation conceptual models between stakeholders effectively. A good conceptual model representation may be used as a legal document in a simulation project contract; it may be used ...
Onggo, B S S
core  

Can involving clients in simulation studies help them solve their future problems? A transfer of learning experiment [PDF]

, 2015
It is often stated that involving the client in operational research studies increases conceptual learning about a system which can then be applied repeatedly to other, similar, systems.
Adamides, Andersen, Argyris, Bakken, Barnett, Bassok, Bendoly, Brailsford, Churchman, den Hengst, Field, Franco, Franco, Franco, Franco, Gick, Gick, Günal, Günal, Hoad, Hovmand, Hämälläinen, Jahangirian, Kathy Kotiadis, Katsaliaki, Korzilius, Kotiadis, Lane, Lane, Langley, Monks, Onggo, Petty, Pidd, Robinson, Robinson, Robinson, Robinson, Robinson, Rouwette, Rouwette, Rouwette, Rouwette, Scott, Shields, Shields, Stewart Robinson, Thomas Monks, van der Zee, van der Zee   +49 more
core   +2 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

A framework of web-based conceptual design [PDF]

, 2003
A web-based conceptual design prototype system is presented. The system consists of four parts which interpret on-line sketches as 2D and 3D geometry, extract 3D hierarchical configurations, allow editing of component behaviours, and produce VRML-based ...
A.A. West, Bender, Chen, D.K. Wright, Deng, Dorsey, Eggli, Hwang, I.N. Jordanov, Jenkins, Kilingstam, Qin, R. Harrison, Rezayat, S.F. Qin, Umeda, Van Dijk, Weyrich   +17 more
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Demonstration test catchments : the role of hydrogeological conceptual modelling [PDF]

, 2012
Agricultural diffuse pollution, particularly from nitrate and phosphate, is a significant problem in the UK and is the focus of the national Demonstration Test Catchments (DTC) study — a UK Government initiative.
Allen, David, Gooddy, Daren
core