Results 91 to 100 of about 31,544 (264)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Representation of the “fire” concept in Russian language picture of the world
КавказологияThe article investigates the characteristics of the representation of the notion "Fire" in the Russian linguistic vision of the world. Fire is an essential component of civilization and one of the fundamental concepts that holds universal worth ...
Fatimat V. Shogenova
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
ЛИНГВОКОГНИТИВНЫЙ подход К ИЗУЧЕНИЮ РЕГИОНАЛЬНОЙ ОНОМАСТИКИ
Studia Rossica Posnaniensia, 2018 The author analyses the part of Tambov Region onomasticon - that is personal nickname-like proper names. Onomasiological types of nicknames, reason for their emergence, their connection to specific social groups and gender have been presented in the ...
АНТОНИНА ЩЕРБАК
doaj
“AUTHOR'S CONSCIOUSNESS” AND THE SEMANTIC CENTER OF AN AUTOBIOGRAPHICAL WORK
Известия Южного федерального университета: Филологические наукиThe essence of the conceptual and figurative concept in linguistic and literary approach is studied. The conceptual-figurative concept is one of the units that fill the figurative-semantic system of the author. Its function in an autobiographical work is
Natalia V. Sklyar
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Scientific Journal of Polonia University, 2018 The article analyzes and summarizes the views of Ukrainian and foreign linguists concerning the language structure and conceptual world pictures peculiarities. The paper focuses on the existence of general and specific in language. The role of culture in the formation and evolution of national world pictures and the influence of the national ...
openaire +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source