Results 71 to 80 of about 31,544 (264)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Planning sentences and sentence intonation in Estonian
Laboratory PhonologyThe notion of advance planning of sentence intonation is grounded in the positive correlation between the sentence-initial intonation peaks and sentence duration.
Nele Ots
doaj +2 more sources
CONCEPTUAL PICTURE OF THE WORLD: THE TYPES OF RELATIONS THAT ARISE IN THE INTERACTION OF OBJECTS
Young Scientist, 2018 The presence of a connection between the concept and the image of the word gives the opportunity to say that the word reflects (induces) the concept in the human consciousness. The relations that arise between a word and its image in the human consciousness are causal, and the word and its image in the human consciousness form, thus, the causal system.
openaire +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
THE TYPES OF CONCEPTS AND THE STAGES OF CONCEPTUAL STRUCTURE ANALYSIS
Вестник Кемеровского государственного университета, 2013 The article deals with the result of modern conceptual investigation of the picture of the world. Two classifications of concepts discussed in the article belong to V. I. Karasik and M. V. Pimenova.
M. V. Pimenova
doaj
ENGLISH CONCEPT HAIR (sociocultural aspect)
Записки з романо-германської філології, 2019 The article is devoted to the consideration of the features of the verbalization of the English concept HAIR. The purpose of the work is to examine the socio-cultural features of the verbalization of the English concept HAIR as a fragment of the English ...
Н. М. Мікава
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source